Autores:
Lucía Gabriela García-Pedraza.
Bertha I. Juárez-Flores.
Juan Rogelio Aguirre R.
Juan Manuel Pinos-Rodríguez.
Jesús Flavio Martínez.
Martha Eugenia Santoyo.
Revista y/o libro:
Journal of Medicinal Plants Research
Volumen:
3(11), 932-940
Año:
2009
Sinopsis:
Forty eight rats were randomly assigned to one of the eight treatments resulting from a complete 2 X 4 factorial arrangement of treatments. In non-diabetic (ND) and streptozotocin-diabetic (D) rats we evaluate HFAS (high-fructose agave syrup) intake on plasma concentrations of diabetes related compounds. HFAS (0.0, 0.5, 2.0 and 5.0 g/kg body weight) was fed daily for six weeks to ND and D rats. Plasma glucose, cholesterol, triglycerides, blood glycosylated hemoglobin (HbA1c), urine albumin and creatinine and liver steatosis were evaluated. Intake decreased linearly in D rats and showed a quadratic trend in ND rats. The HFAS did not affect weight gain. Triglycerides in D rats increased linearly as HFAS doses increased. There were quadratic opposite trends of glucose and HbA1c, as HFAS doses increased; 0.5 g dose had the major impact on these variables. Streptozotocin-diabetic rats fed 2 and 5 g HFAS/kg body weight had lower liver steatosis than those non-supplemented with HFAS. Dietary HFAS did not show negative effects on food intake, weight gain and hiperglucemia in both ND and D rats. Apparently HFAS had a protective effect on steatosis in D rats.