Agave tequilana fructans reversed disorders metabolic in overweight mice by to increase in short chain fatty acids and hormones that promotes satiety

The aim of this study was assess the effect of Agave fructans and a shift of diet on metabolic parameters in overweight mice. Firstly, C57BL6 mice were feed to a standard diet (CG) or high fat (HF) diet during 5 weeks, with the finality to induce overweight in the animals, followed of a shift of diet (HF→STD) and a treatment with Agave (HF→ATJ) or chicory (HF→OFS) fructans for additional period of 5 weeks. The HF group showed a body weight gain of 30% and an increased in concentration of glucose, triglycerides and cholesterol by 8%, 79% and 34% respectively compared to the CG group. Only the overweight mice that received the treatments ATJ or OFS reversed the metabolic disorders induced by consuming of a HF diet, reaching values very close to CG group. In addition, ATJ and OFS treatments lead to a higher concentration of SCFAs in the gut content and modulate the hormones GLP-1 and leptin involved with the food intake regulation.